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All about the endocannabinoid system 

What is the endocannabinoid system?

The endocannabinoid system is made up of receptors located in numerous areas of our body. Their activation requires phytocannabinoids — endogenous substances produced by the body or supplied externally in synthetic products. The endocannabinoid system integrates physiological functions. They are related to the body’s response to diseases and injuries. It maintains and restores the state of homeostasis and a general sense of well-being. Also, emotional balance, physical and mental health. The endocannabinoid system was discovered in the human body in 1992. Scientists wondering how cannabinoids (THC, CBD) affect the human body have discovered some receptors. Despite playing an important role in the body, it is only nowadays to understand how it works. And understand how important it is for the proper functioning of the body.

How does the endocannabinoid system work?

The endocannabinoid system is believed to be the bridge between the physical body and the human mind. The endocannabinoid system is responsible for the regulation and balance of almost all processes in the human body. It affects, among others on appetite, sleep, metabolism, memory, reproductive function, cardiovascular function and immune response. The endocannabinoid system starts when there is an imbalance, e.g. during fever or sleep disorders. The endocannabinoid system consists of three components: receptors, cannabinoids, and enzymes. The body must produce an appropriate chemical substance. It is to activate the receptor’s work and initiate the process for which it is responsible. Receptors can be “cheated” a bit — they can be compared to a lock with several keys. In the endocannabinoid system. This system is no exception, just like opioid receptors, stimulated by poppy preparations, work in our bodies. There are two types of endocannabinoid receptors CB1 and CB2, located in our body.

Endocannabinoids, as the name suggests, are endogenous substances, i.e. substances produced naturally by our body. CB1 receptors are found primarily in the brain, specifically in the hypothalamus and amygdala. These areas of the brain are responsible for controlling appetite as well as memory and emotional processing. In addition, CB1 receptors are also found in the central nervous system (nerve endings). There they are responsible for the perception of pain. CB2 receptors are found mainly in the immune system. Activation of these receptors starts stimulating the immune system to fight inflammation and initiates other immune actions. This type of receptor is also found in the peripheral nervous system. They are suitable endogenous cannabinoids that effectively mimic their effects. Knowledge in this matter is rapidly developing. It is estimated that cannabis contains about 540 chemical compounds and over 90 cannabinoids. Enzymes are responsible for destroying endocannabinoids when the body uses them. There are two metabolic enzymes: F AAH and M AGL.

How do you stimulate the endocannabinoid system?

The endocannabinoid system plays a fundamental role in maintaining the balance of human physiology. But what happens if the endocannabinoid system is thrown out of balance? Research suggests that everyone has an optimal “endocannabinoid tone.” This is a term that describes the volume of cannabinoids produced by the body and circulating in it. An endocannabinoid deficiency can lead to a condition known as clinical endocannabinoid deficiency. So how do we keep our endocannabinoid system under control? There are several simple and natural ways to support the ECS. The first way is through phytocannabinoids like CBD that affect cannabinoid receptors. Research suggests they may be useful in cases of low endocannabinoid tone. Another way is to eat a diet rich in omega fatty acids. The body needs omega-3 fatty acids to synthesize endocannabinoids. Foods high in omega-3s include fish, hemp seeds, walnuts, flaxseeds, chia seeds, and caviar. Another option is aerobic exercise such as running or cycling. They can be simple ways to increase the levels of anandamide in the brain. And another way is caryophyllene, a terpene found in many herbs used in cooking and cannabis. Caryophyllene also acts as a cannabinoid by binding directly to the CB2 receptor. This mechanism of action allows the substance to calm the nerves and improve mood. High levels of this molecule include rosemary, black pepper, hops, cloves and oregano.